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Coadministration of encorafenib with delicate CYP3A4 substrates might end in elevated toxicity or decreased efficacy of these agents.Lonafarnib might boost the AUC and peak focus of CYP2C19 substrates. If coadministration unavoidable, check for adverse reactions and reduce the CYP2C19 substrate dose in accordance with its accepted item labeling.nev